Yahoo Finance: Agilent Receives FDA Approval for PD-L1 IHC 22C3 pharmDx in Esophageal or Gastroesophageal Junction (GEJ) Carcinoma Agilent Receives FDA Approval for PD-L1 IHC 22C3 pharmDx in Esophageal or Gastroesophageal Junction (GEJ) Carcinoma ascopubs.org: Organ Preservation for Gastroesophageal Junction and Gastric Cancers: Ready for Primetime? Organ preservation for gastroesophageal junction (GEJ) and gastric cancers is emerging as an attainable—but still selective—therapeutic goal. The convergence of effective systemic therapy, enhanced ...

Understanding the Context

Business Wire: TEVIMBRA Approved in U.S. for First-line Treatment of Gastric and Gastroesophageal Junction Cancers in Combination with Chemotherapy TEVIMBRA Approved in U.S. for First-line Treatment of Gastric and Gastroesophageal Junction Cancers in Combination with Chemotherapy The New England Journal of Medicine: Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer Perioperative FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) is a standard therapy for resectable gastric and gastroesophageal junction adenocarcinomas, but recurrence rates remain high. Cure Today: FDA Approves Tevimbra Plus Chemo for Gastric, Gastroesophageal Junction Adenocarcinoma Tevimbra approved for HER2-negative gastric or gastroesophageal junction adenocarcinoma with PD-L1 expression, in combination with chemotherapy.

Key Insights

Phase 3 trial showed Tevimbra improved median overall ... ascopubs.org: Outcomes of metastatic esophageal and gastroesophageal junction cancers: A 13-year single-center study. Outcomes of metastatic esophageal and gastroesophageal junction cancers: A 13-year single-center study. ascopubs.org: Neoadjuvant, adjuvant and perioperative systemic therapies in gastric and gastroesophageal junction adenocarcinoma: A network meta-analysis of randomized controlled trials. Neoadjuvant, adjuvant and perioperative systemic therapies in gastric and gastroesophageal junction adenocarcinoma: A network meta-analysis of randomized controlled trials.

Final Thoughts

SKB264 led to durable responses and a manageable safety profile in patients with gastric or gastroesophageal junction cancers, an expert said. Treatment with the antibody-drug conjugate (ADC) SKB264 ... Nasdaq: IMFINZI® (durvalumab) plus chemotherapy significantly improved pathologic complete response in gastric and gastroesophageal junction cancers in MATTERHORN Phase III trial IMFINZI® (durvalumab) plus chemotherapy significantly improved pathologic complete response in gastric and gastroesophageal junction cancers in MATTERHORN Phase III trial Nasdaq: BeiGene’s Biologics License Application for TEVIMBRA® (tislelizumab) for First-Line Gastric or Gastroesophageal Junction Cancers Accepted by FDA BeiGene’s Biologics License Application for TEVIMBRA® (tislelizumab) for First-Line Gastric or Gastroesophageal Junction Cancers Accepted by FDA